SI Appendix: Phenotypic switching in gene regulatory networks
نویسندگان
چکیده
3 Slow promoter fluctuations 5 3.1 Binary promoter switching: exact solution . . . . . . . . . . . . . . . . . . . . . . . . . . . . 7 3.2 General solution using the conditional LNA . . . . . . . . . . . . . . . . . . . . . . . . . . . 8 3.2.1 Conditional gene product distribution . . . . . . . . . . . . . . . . . . . . . . . . . . 8 3.2.2 Distribution of promoter states . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 9 3.2.3 Distribution of expression products . . . . . . . . . . . . . . . . . . . . . . . . . . . . 10 3.3 Modes of distribution . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 10 3.4 Binary promoter switching: approximate solution . . . . . . . . . . . . . . . . . . . . . . . . 10 3.5 Moments of distribution . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 12 3.6 Time correlation functions and power spectra . . . . . . . . . . . . . . . . . . . . . . . . . . 12 3.7 Multiple identical gene copies . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 14
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